Lou, the assistant to the head of a feminist group, sees ants all over herself. She starts screaming but obviously nobody else sees the ants. Meanwhile at the hospital, Wilson returns for the first time since Amber’s death. House wants Lou’s case but Cuddy would prefer him to spend the time talking to Wilson.
House quickly believes that Lou is suffering from a B-12 deficiency due to her strong career. He tells the other doctor’s about Thirteen’s Huntington’s disease. Lou continues to work even when she is in the hospital because she wants to matter. She starts bleeding out of her rectum. House finally talks to Wilson but Wilson tells him he’s resigning and maybe even moving out of the state. House tries to tell him that a change of venue won’t help him and that his grief is talking. Due to this news, House spends much of the episode trying to convince and threaten Wilson to stay. This means he has little time for the patient and his team has to pick up the slack. They do find out that the patient is pregnant and House tells them to remove the fetus (that is in the fallopian tubes by the way) and if she survives the surgery she will be fine. They do so and the patient seems fine for awhile.
House tries to get Cuddy to talk Wilson out of leaving. She tells him to apologize but House doesn’t think it was his fault at all. Lou is still sick since she keeps blinking. The pregnancy was just a coincidence. She has a seizure but House doesn’t care enough to help. In fact, he tells Wilson that he is going home and won’t help the patient until he agrees to stay. He isn’t bluffing as he does leave and refuses to answer the phone. Cuddy hands the case over to Foreman and House’s team. Thirteen thinks it is MS and Foreman okays treatment for it. However, just before treatment Lou starts to shiver and has a slight fever. This rules out MS.
Cuddy gets House and Wilson into the same room and starts a “couples therapy” session for them. House’s team watches Lou’s surgery over again and Kutner sees an abnormal growth. They’ll have to open her up again to get a piece of the growth. The first couples session doesn’t go well. Neither House or Wilson really talk and Wilson ends up leaving.
Foreman and the team ask Chase to open Lou up again but he doesn’t think he missed anything. Plus, she wouldn’t be able to survive another round of anesthesia anyway. Kutner thinks of another way to do it without putting Lou under anesthesia. The team does the procedure and they get a piece of the growth.
Cameron tells Wilson not to go. House was right when he told him that the pain doesn’t go. Since she lost her husband, she should know. Lou could still have a few different diseases. Foreman asks Wilson to make the call. He guesses lymphoma so they start chemo. Foreman tells Wilson he should leave it if will make his life a little easier.
Lou starts to feel better but House returns with a diagnosis other than cancer. He says it is “pretty” leprosy, a disease that makes you look younger than you are (he was shocked by her age earlier and now he knows why). All she needs to take is a few antibiotics and she’ll be fine. Tests confirm House’s diagnosis.
House actually apologizes to Wilson. He tells him he feels like crap and thinks Amber died because of him. Wilson doesn’t blame him at all. However, the two aren’t okay. He has always tried to protect house by enabling him. He learned from Amber that he needs to start taking care of himself. House is no longer his friend and maybe never was. Wilson packs up and leaves.
